Table 3.
Multivariate Analysis of Factors Associated with Disease Progression and Hepatocellular Carcinoma Development by Cox Regression Model
| Factor | Disease progression | HCC development | ||
|---|---|---|---|---|
|
|
|
|||
| Adjusted HR (95% CI) | p-value | Adjusted HR (95% CI) | p-value | |
| Age, >50 yr | 1.05 (1.02–1.07) | <0.001 | 1.05 (1.01–1.10) | 0.016 |
| Family history of HCC | - | - | 5.48 (2.13–14.09) | 0.004 |
| Cirrhosis | 2.95 (1.48–5.88) | 0.002 | 17.16 (4.67–63.12) | <0.001 |
| Duration of maintained virological response (>12 mo) | 0.19 (0.09–0.37) | <0.001 | 0.09 (0.04–0.21) | <0.001 |
HCC, hepatocellular carcinoma; HR, hazard ratio; CI, confidence interval.