Table 3.
Hazard ratios (HRs) and 95% confidence intervals (CI) for the associations between elevated Cystatin C (Cyst-C >1.12 mg/dL) and rates of sepsis
| Variable | Unadjusted Models | Add sociodemographics* | Add health behaviors † | Add chronic medical conditions ‡ | Add eGFR and ACR | Add hsCRP | Add eGFR, ACR and hsCRP |
|---|---|---|---|---|---|---|---|
| Cystatin C ≤1.12 mg/dL | Referent | Referent | Referent | Referent | Referent | Referent | Referent |
| Cystatin C >1.12 mg/dL | 2.70 (2.43-3.00) | 2.12 (1.89-2.37) | 2.06 (1.84-2.31) | 1.75 (1.55-1.96) | 1.57 (1.38-1.79) | 1.67 (1.48-1.87) | 1.51 (1.32-1.72) |
| eGFR≥60 ml/min/1.73m2 | Referent | Referent | Referent | ||||
| eGFR<60 ml/min/1.73m2 | 2.38 (2.10-2.70) | --- | --- | --- | 1.13 (0.98-1.32) | --- | 1.14 (0.98-1.32) |
| ACR <30 mg/g | Referent | Referent | Referent | ||||
| ACR ≥30 mg/g | 2.22 (1.97-2.49) | --- | --- | --- | 1.57 (1.38-1.79) | --- | 1.45 (1.28-1.65) |
| hsCRP ≤3.0 mg/dL | Referent | Referent | Referent | ||||
| hsCRP >3.0 mg/dL | 1.71 (1.54-1.90) | --- | --- | --- | --- | 1.51 (1.35-1.68) | 1.48 (1.32-1.65) |
Estimates pooled after multiple imputation using Rubin’s rules, total of 29,696 REGARDS participants included in the analysis. *Age, sex, race, region, income, education. †Tobacco and alcohol use. ‡History of cancer, chronic lung disease, coronary artery disease, diabetes, dyslipidemia, hypertension, myocardial infarction, obesity, stroke. eGFR = estimated glomerular filtration rate. ACR = albumin-to-creatinine ratio. hsCRP = high sensitivity C-reactive protein. Cyst-C levels ranged from 0.1 to 11.9 mg/dL.