Table 4.
Sensitivity analysis
| Variable | Unadjusted | Model 1 | Model 2 | Model 3 | Model 4 | Model 5 |
|---|---|---|---|---|---|---|
| Cystatin C ≥1.12 mg/dL | 2.70 (2.43-3.00) | 1.51 (1.32-1.72) | 1.60 (1.40-1.83) | |||
| Cystatin C Quartiles | ||||||
| Q1 (<0.83 mg/dL) | Ref | Ref | Ref | |||
| Q2 (0.83-0.94 mg/dL) | 1.40 (1.16-1.69) | 1.14 (0.94-1.37) | 1.14 (0.94-1.38) | |||
| Q3 (0.95-1.12 mg/dL) | 1.81 (1.51-2.17) | 1.20 (0.96-1.45) | 1.22 (1.01-1.47) | |||
| Q4 (>1.12 mg/dL) | 3.77 (3.20-4.45) | 1.72 (1.42-2.09) | 1.85 (1.51-2.27) | |||
| Cystatin C (per SD) (mg/dL) | 1.24 (1.21-1.27) | 1.16 (1.11-1.21) | ||||
| eGFR <60 ml/min/1.73m2 | 2.38 (2.10-2.70) | 1.14 (0.98-1.32) | 1.14 (0.98-1.32) | |||
| ACR ≥30 mg/g | 2.22 (1.97-2.49) | 1.45 (1.28-1.65) | 1.45 (1.28-1.65) | |||
| hsCRP >3.0 mg/dL | 1.71 (1.54-1.90) | 1.48 (1.32-1.65) | 1.47 (1.31-1.64) | |||
| eGFR <73.1 ml/min/1.73m2 | 1.91 (1.72-2.12) | 1.00 (0.87-1.14) | 0.98 (0.86-1.12) | |||
| ACR ≥16.1 mg/g | 2.05 (1.85-2.28) | 1.41 (1.26-1.58) | 1.41 (1.26-1.58) | |||
| hsCRP >5.0 mg/dL | 1.75 (1.57-1.95) | 1.51 (1.34-1.69) | 1.49 (1.33-1.68) | |||
| eGFR (per SD) (ml/min/1.73m2) | 0.69 (0.65-0.72) | 0.97 (0.90-1.04) | ||||
| ACR (per SD) (mg/g) | 1.07 (1.03-1.11) | 1.01 (0.97-1.06) | ||||
| hsCRP (per SD) (mg/dL) | 1.12 (1.10-1.15) | 1.10 (1.06-1.14) |
Hazard ratios (HRs) and 95% confidence intervals (CI) for the associations between Cystatin-C levels and rates of sepsis.
Estimates pooled after multiple imputation using Rubin’s rules. Total of 29,696 REGARDS participants included in the analysis. Except for unadjusted model, all models adjusted for sociodemographics, health behaviors, and chronic medical conditions. eGFR = estimated glomerular filtration rate. ACR = albumin-to-creatinine ratio. hsCRP = high sensitivity C-reactive protein. Cyst-C levels ranged from 0.1 to 11.9 mg/dL.
Model 1 – Primary model; binary Cyst-C; binary eGFR, ACR and hsCRP using clinical cutpoints.
Model 2 – Cyst-C quartiles; binary eGFR, ACR and hsCRP using clinical cutpoints.
Model 3 – Binary Cyst-C; binary eGFR, ACR and hsCRP using 75th percentile as cutpoints.
Model 4 – Cyst-C quartiles; binary eGFR, ACR and hsCRP using 75th percentile as cutpoints.
Model 5 – Continuous Cyst-C, eGFR, ACR and hsCRP, normalized by standard deviation.