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. Author manuscript; available in PMC: 2015 Apr 29.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Nov 22;20(2):591–593. doi: 10.1016/j.bmcl.2009.11.083

Scheme 1.

Scheme 1

Synthesis of (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-one analogs: Reagents and conditions (a) appropriate benzyl halide, aqueous NaOH solution, triethylbenzyl ammonium chloride, DCM, RT; (b) creatinine (1.1 mol. eq), NaOAc (1.2 mol. eq), AcOH, MWI, 30–60 sec; (c) creatinine (1.1 mol. eq), NaOAc (1.2 mol. eq), AcOH, reflux, 7–10 h.