Contribution of the extrinsic and intrinsic coagulation pathways to hemostasis after laser injury. Vascular lesions were induced in wild-type (WT) (black line/symbols), TFlow (red) and FIX−/− (blue) mice. (A) Representative images. (B, C) Accumulation of platelets (B) and fibrin (C). Sum fluorescence intensity (SFI) ± standard error of the mean is shown. TFlow: n = 9 (three mice). FIX−/−: n = 13 (three mice). (D) Bleeding time. *P < 0.05, **P < 0.001, ***P < 0.0001. GP, glycoprotein; TF, tissue factor.