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. 2015 Jan 23;6(6):3493–3506. doi: 10.18632/oncotarget.3051

Figure 3. A possible model illustrating GOLPH3 function during cytokinesis.

Figure 3

Wild type function of the PI4KIIIβ (named Fwd in Drosophila) is required for PI(4)P synthesis at the Golgi. Recruitment of GOLPH3 to the Golgi depends on PI(4)P. Fwd protein binds Rab11 and recruits this protein on Golgi membranes. Wild type function of GOLPH3 is required to recruit PI(4)P-and Rab11-containing secretory organelles to the cleavage furrow. PI(4)P is the immediate precursor of PI(4,5)P2 that is generated in the cleavage furrow by PI(4)P 5-kinase. Binding to phosphatidic acid (PA), GOLPH3 might also contribute to PI(4)P 5-kinase activation and plasma membrane remodeling. PI(4)P-GOLPH3 and PI(4,5)P2 mediate the interaction of centralspindlin, septins and actomyosin with the plasma membrane at the cleavage site, playing a crucial role in contractile ring formation.