Figure 2. EGFR and Cofilin-1 cytosolic and nuclear crosstalk.

Schematic representation of EGFR and cofilin-1 pathways intersections. Different local stimuli may result in cofilin-1 modulation through EGFR activation. Downstream EGFR pathways may activate cofilin-1 through dephosphorylation by SSH1 and release of cortactin and PIP₂ bounds by intracellular pH alteration; also, it may result in cofilin-1 inactivation by LIMK activity. Cofilin-1 and EGFR may also translocate into nucleus in response to external stimuli, indicating a possibility of related mechanisms of drug resistance.