Table 2. Summary of linkage studies on healthy aging and longevity.

Phenotype	Location	LOD score (P-value)	Reference
Longevity	4q25	3.65 (4.4 × 10−2)a	[58]
Healthy aging	4q25	1.67 (3.0 × 10−3)b	[23]
Longevity	3p24.2–22.3	4.02 (3.7 × 10−2)c	[5]
	9q31.3–34.2	3.89 (5.4 × 10−2)c
Successful aging	Chromosome 6,	4.49d, †	[24]
	7	3.11e
	14	4.17e
Successful aging	Chromosome 6,	3.24d, †	[59]
	10,	4.2e
	16	3.3d
	17,	3.5e
	20	3.3e
Longevity	3p24–22	4.19 (1.0 × 10−5)f	[60]
Longevity	14q11.2	3.47g	[61]
	17q12–22	2.95g
	19p13.3–p13.11	3.76g
	19q13.11–q13.32	3.57g
Healthy aging	12p13–14	3.0 (1.0 × 10−4)h	This study

^anon-parametric (empirical P value);

^bnon-parametric (point-wise P value);

^cnon-parametric, Kong & Cox LOD score – exponential model (empirical P value);

^dHLOD;

^eNPL statistic in MERLIN;

^fZ-score (point-wise P value);

^gnon-parametric;

^hnon-parametric, Kong & Cox LOD score – linear model (point-wise P value):

^†Different regions