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. 2015 Jan 21;6(6):3797–3810. doi: 10.18632/oncotarget.2902

Figure 6. Expression pattern of V-ATPase V0a1 and V0a3 isoforms in ovarian cancer tissues.

Figure 6

Immunohistochemical analysis of V0a1 and a3 isoforms in human ovarian cancer tissues. (A) V0a1 expression was assessed using anti-V0a1 antibody against 74–93 amino acids. Control panel (i, ii)- Normal ovarian tissue, (iii)-benign granulosa of the ovary. Ovarian cancer panel (i) grade I serous cystedenocarcinoma. (ii) stage III endometroid cystedenocarcinoma, (iii) grade II serous cystedenocarcinoma. (B) V0a3 expresssion was assessed using anti-V0a3 antibody against 696–715 amino acids. Control panel shows (i), (ii)- Normal ovarian tissue, (iii)-benign granulosa cell tumor of the ovaries. Ovarian cancer panel shows (i) grade I serous cystedenocarcinoma. B(ii, iii) grade II serous cystedenocarcinoma. Unlike V-ATPase-V0a2 expression, the normal and benign OVCA tissues also exhibited some levels of V0a1 and V0a3 expression although, lower than metastatic tissues. Original magnification: × 400; scale bars –50 μm. The following Tissue Array was used: human ovary tumor tissue array; Biochain (Cat no: Z7020088).