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. 2015 Feb 2;6(6):3840–3847. doi: 10.18632/oncotarget.2927

Figure 3. MicroRNA-153 regulates WWOX expression.

Figure 3

(A) Computer prediction of miR-163 binding sites in the 3′-UTRs of human WWOX genes. Potential binding sites were highlighted in bold. (B–C) Western blot analysis of WWOX expression in HepG2 cells transfected with miR-153 mimics (B), antisense (C) or negative control (NC). (D) Luciferase reporter assays in HepG2 cells. Cells were transfected with 100 ng of wild-type 3′-UTR-reporter or mutant constructs together with miR-153 mimics, antisenseor negative control (NC).