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. 2014 Dec 27;6(6):4144–4158. doi: 10.18632/oncotarget.2864

Figure 7. Schematic model of miR-191-mediated promotion of tumorigencity of colorectal cancer cells.

Figure 7

In colorectal cancer cells, various anticancer drugs regulate the expression of miR-191. miR-191 causes a number of genes to respond and adapt. On one hand, miR-191 induces the expression of CDK4 to increase cell growth. On the other hand, miR-191 suppresses the level of C/EBPβ, a tumor suppressor gene functions as a transcriptional activator of p15, p16 and p57, which are the key regulators of cell cycle and cell survival. As a result, miR-191 induces the cell cycle progression and tumor cell resistance to various stimuli.