Table 2. Crude and adjusted area under the ROC curve (AUC) values by cancer site.
Area under the ROC curve (AUC). Cancer vs. normal tissue* | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Average methylation percentage across all 27 CpGs | Methylation percentage of GHSR_−1620 | Average methylation percentage across four most hypermethylated consecutive CpGs in exon 1** | ||||||||
Malignancy | n | Crude | (95% CI) | Age-adjusted | Crude | (95% CI) | Age-adjusted | Crude | (95% CI) | Age-adjusted |
Breast | 20 | 0.9400 | 0.8181–1.0000 | 0.9800 | 0.9800 | 0.9329–1.0000 | 1.0000 | 0.9900 | 0.9623–1.0000 | 1.0000 |
Lung | 29 | 0.9905 | 0.9679–1.0000 | 0.9952 | 1.0000 | 1.0000–1.0000 | 0.9692 | 0.9762 | 0.9263–1.0000 | 0.9952 |
Pancreas | 18 | 1.0000 | 1.0000–1.0000 | 1.0000 | 1.0000 | 1.0000–1.0000 | 1.0000 | 1.0000 | 1.0000–1.0000 | 1.0000 |
Colorectum | 33 | 0.7976 | 0.6406–0.9546 | 0.8095 | 0.6726 | 0.4815–0.8637 | 0.7341 | 0.8016 | 0.6469–0.9562 | 0.8492 |
Prostate | 17 | 0.8667 | 0.6320–1.0000 | 0.8833 | 0.9667 | 0.8879–1.0000 | 0.9667 | 0.8909 | 0.6683–1.0000 | 0.8909 |
CLL | 15 | 0.9400 | 0.8123–1.0000 | NC | 0.9600 | 0.8681–1.0000 | NC | 0.5600 | 0.2420–0.8779 | NC |
All cancers | 132 | 0.8789 | 0.8206–0.9372 | 0.8862 | 0.8640 | 0.8001–0.9280 | 0.8776 | 0.8759 | 0.8177–0.9341 | 0.8907 |
NC: Not calculable. Brain samples were not included in the analysis due to the lack of normal tissues.
For CLL, B cells of healthy donors were employed as control.
GHSR_+249, GHSR_+251, GHSR_+257, GHSR_+259 were considered