Table 2. Survival analysis of 300 GC patients with MSP detection of ZNF545 promoter methylation.
| Variables | Median OS (mo) | X2 value | Univariate P value | HR value | Multivariate P value |
|---|---|---|---|---|---|
| Gender | |||||
| Male | 23 | 3.922 | 0.048 | ||
| Female | 17 | ||||
| Age at surgery (years) | |||||
| ≤ 60 | 19 | 0.193 | 0.661 | ||
| > 60 | 24 | ||||
| Tumor location | |||||
| Upper third | 22 | 1.846 | 0.605 | ||
| Middle third | 16 | ||||
| Lower third | 24 | ||||
| ≥ 2/3 stomach | 12 | ||||
| Tumor size (cm) | |||||
| < 4.0 | 26 | 1.054 | 0.305 | ||
| ≥ 4.0 | 21 | ||||
| Lauren classification | |||||
| Intestinal | 24 | 3.513 | 0.173 | ||
| Diffuse | 20 | ||||
| Mixed | 24 | ||||
| Depth of tumor invasion (T stage) | |||||
| T1 | 46 | 21.861 | < 0.001 | 1.432 (1.159–1.769) | 0.001 |
| T2 | 25 | ||||
| T3 | 24 | ||||
| T4 | 14 | ||||
| Number of metastatic lymph nodes (N stage) | |||||
| N0 | 34 | 59.155 | < 0.001 | 1.520 (1.343–1.721) | < 0.001 |
| N1 | 23 | ||||
| N2 | 17 | ||||
| N3 | 9 | ||||
| Location of lymph node metastasis | |||||
| No | 34 | 27.942 | < 0.001 | ||
| Perigastric | 20 | ||||
| Extragastric | 15 | ||||
| ZNF545 promoter methylation | |||||
| Hypermethylation | 11 | 20.267 | < 0.001 | ||
| Hypomethylation | 21 | ||||
| Non-methylation | 25 | ||||