HucMSC-Ex prompted the migration of endothelial cells. (A): EA.hy926 cells were treated with different concentrations of exosomes (80, 160 μg/ml) or PBS for 12 hours. Transwell migration assay was performed to analyze the migratory ability of the cells (×100). Cells that migrated to the bottom were counted. ∗∗, p < .01; ∗∗∗, p < .001. (B): EA.hy926 cells treated with different concentrations of exosomes (80, 160 μg/ml) were subjected to a wound-healing assay for 12 hours (×100), and the percentage of closure of the wounded areas was measured. ∗∗, p < .01; ∗∗∗, p < .001. Abbreviations: hucMSC-Ex, exosomes from human umbilical cord mesenchymal stem cells; PBS, phosphate-buffered saline.