Table 1.

Adverse events: Over the course of the study, at least one adverse event which occurred at least one time was recorded for 20 of 36 patients that completed the trial (55.5%). These may have been listed on only one or on repeated surveys. No dogs were removed from the trial due to adverse events.

Adverse event/sign	Number of dogs with event/sign reported	Percentage of dogs with event/sign reported
Gastrointestinal
Soft stool, loose stool, diarrhea	1	2.7
Constipation	1	2.7
Increased thirst	1	2.7
Behavioral
Anxiety/restlessness/agitation	2	5.4
Aggression*	1	2.7
Moaning	1	2.7
Drowsy	2	5.4
Drugged/spacey*	5	13.5
Other
Panting	2	5.4
Teeth chattering*	1	2.7
Drooling	1	2.7
Paranoid	1	2.7
Leaking urine	1	2.7

^*One unexplained case of aggression/drugged/teeth chattering was associated with single administration of a 300 mg generic trazodone tablet obtained by the client from a local pharmacy. These signs did not re-appear when the prescription was filled for the same dose (300 mg) using three 100 mg tablets from NCSU pharmacy.