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. 2015 Mar 17;16(1):195. doi: 10.1186/s12864-015-1364-0

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© Zhou et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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NRF2-mediated oxidative stress response. A. The Keap1-NRF2 pathway from IPA software. Canonical pathway analysis identified that the Keap1-NRF2 pathway was statistically significant with P-value = 6.96E-04. Red and green symbols indicate genes up- and down-regulated in the high-FE chickens, respectively. The color intensity is proportional to the degree of fold change. B. NRF2 (NFE2L2) is predicted to be activated in the high-FE chickens by Ingenuity Upstream Regulator Analysis.