Table 1.
Effect of MPE and VTE on wound contraction, epithelization period and scar area in rats: excision wound study
| Oral treatment (mg/kg, od) | Wound area in mm 2 /rat | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Before treatment 0 day | After treatment | F values * | P values * | ||||||||
| 4 th day | 8 th day | 12 th day | 14 4h day | 16 th day | 18 th day | 20 th day | 22 nd day | ||||
| Control (CMC) | 531.2±7.9 | 432.8±8.9 | 308.1±15.1 | 201.3±11.4 | 125.2±9.1 | 91.7±4.8 | 44.7±2.4 | 18.7±2.4 | 5.5±0.3 | 486.4 | 0.000 |
| (100.0±0.0) | (74.3±2.4) | (51.2±2.6) | (31.7±2.1) | (19.8±0.9) | (14.4±1.3) | (6.6±0.5) | (2.0±0.5) | (0.7±0.1) | |||
| MPE (200) | 521.7±7.7 | 321.5±4.6c | 198.5±6.6c | 114.5±6.7c | 83.7±4.2c | 44.2±3.6c | 20.8±1.4c | 4.2±0.3c | 0.0±0.0c | 1692.0 | 0.000 |
| (100.0±0.0) | (59.9±0.9) | (35.0±1.0) | (18.4±1.2) | (13.9±0.7) | (5.7±0.7) | (3.3±0.3) | (0.6±0.1) | (0.0±0.0) | |||
| VTE (200) | 543.7±9.6 | 314.0±8.2c | 187.8±10.9c | 103.3±3.9c | 43.3±5.9c | 35.3±3.1c | 6.7±0.6c | 0.7±0.1c | 0.0±0.0c | 926.0 | 0.000 |
| (100.0±0.0) | (53.5±1.5) | (25.5±2.1) | (17.4±0.8) | (5.2±1.2) | (4.6±0.6) | (0.9±0.1) | (0.1±0.02) | (0.0±0.0) | |||
Values are mean ± SEM (n= 6). Values in parenthesis indicate mean ± SEM percent of respective 0 day value using repeated measure ANOVA.
Statistical analysis was done by repeated measure ANOVA* in between the group as indicated by P and F values in the table while, one way analysis of variance for multiple comparisons was applied between groups (P c< 0.001 compared to respective day control group).