Table 2.

Incidence of End Points by Categories of 24-Hour Ambulatory Blood Pressure

End Point	Normotension	Isolated Diastolic Hypertension	Mixed Hypertension	Isolated Systolic Hypertension
Number of participants	5969	408	1071	893
Total mortality
Number of deaths	493	25	204	205
Rate	7.3 (6.6–7.9)	6.0 (3.6–8.3)	18.3 (15.8–20.8)‡	22.0 (19.0–25.0)‡
Cardiovascular mortality
Number of deaths	151	11	101	93
Rate	2.2 (1.9–2.6)	2.6 (1.1–4.2)	9.1 (7.3–10.8)‡	10.0 (7.9–12.0)‡
Noncardiovascular mortality
Number of deaths	328	14	100	106
Rate	4.8 (4.3–5.4)	3.4 (1.6–5.1)	9.0 (7.2–10.7)‡	11.4 (9.2–13.5)‡
All cardiovascular events
Number of events	329	28	200	187
Rate	4.9 (4.4–5.5)	6.8 (4.3–9.4)	18.9 (16.3–21.5)‡	21.1 (18.1–24.1)‡
Cardiac events
Number of events	211	24	124	118
Rate	3.1 (2.7–3.6)*	5.9 (3.5–8.2)	11.5 (9.5–13.5)‡	13.1 (10.7–15.4)‡
Coronary events
Number of events	151	19	91	87
Rate	2.2 (1.9–2.6)*	4.6 (2.5–6.7)	8.3 (6.6–10.0)‡	9.5 (7.5–11.5)‡
Stroke
Number of events	106	5	76	69
Rate	1.6 (1.3–1.9)	1.2 (0.1–2.3)	7.0 (5.4–8.6)‡	7.6 (5.8–9.3)‡

Hypertension was a 24-hour ambulatory blood pressure ≥130 mm Hg systolic or 80 mm Hg diastolic. Incidence rates reflect the number of events per 1000 person-years. Significance of the difference with isolated diastolic hypertension:

^*P≤0.05; and

^‡P≤0.001.