Table 3.

Univariate and multivariate Cox hazard regression analysis for prognostic factors

	Univariate analysis		Multivariate analysis
	Hazard ratio (95% confidence interval)	P value	Hazard ratio (95% confidence interval)
Gender
Male vs female	1.349(0.458-3.973)	0.587
Age
≥60 vs <60	1.849(0.760-4.498)	0.176
Smoking
Smoker vs Nonsmoker	0.848(0.250-2.868)	0.790
Drinking
Drinker vs nondrinker	0.818(0.345-1.942)	0.649
Differentiation
Poor vs moderate vs well	0.762(0.415-1.399)	0.381
Tumor depth (PT)
T4vs T3 vs T2 vs T1	2.173(1.380-3.422)	0.001*
Lymph node metastasis
Positive vs negative	4.243(1.844-9.764)	0.001*
Clinical stage
IVvs IIIvs IIvsI	5.513(2.300-13.214)	P < 0.001*	6.998(2.217-22.083)
miR-23a expression
High vs low	7.419(2.561-21.491)	P < 0.001*	6.712(2.076-21.700)

*indicatesP < 0.05.