Table 1. Genes modulated in bdv-p-expressing hNPCs.
| Gene symbol | Encoded protein | Fold change (P/NT) | Function |
|---|---|---|---|
| TH | Tyrosine Hydroxylase | - 42,5 | Dopaminergic neuron marker |
| ApoE | Apolipoprotein E | - 10,1 | Promotes neurogenesis |
| Pou4f1 | POU-domain class 4 transcription factor 1 | - 5,3 | Promotes neurite outgrowth and neuroprotection |
| Tnr | Tenascin R | - 4,5 | Promotes neuronal differentiation and maturation |
| Adora2A | Adenosine A2A Receptor | - 3,9 | Promotes neuronal maturation |
| Bmp4 | Bone Morphogenetic Protein 4 | - 3,5 | Promotes astrocyte differentiation |
| Bdnf | Brain-Derived Neurotrophic Factor | - 3,2 | Promotes neuronal maturation and neuroprotection |
| AchE | Acetylcholinesterase | - 3,2 | Promotes neurite outgrowth |
| Nog | Noggin | - 3,1 | Promotes neurogenesis |
| Olig2 | Oligodendrocyte Lineage Transcription Factor 2 | - 3,1 | Promotes oligodendrocyte differentiation |
PCR array analysis of genes differentially expressed in bdv-p-expressing hNPCs differentiated for 4 days compared with their non-transduced (NT) matched controls.