Table 3.
Case number | Before study aerosol | During study aerosol | After study aerosol | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Surfactant | Inotropes | Pulmonary vasodilators | Ventilator Mode | Maximum Temperature (°C) | Maximum HR (bpm) | Minimum MBP (mmHg) | Duration of study aerosol (hours) | Was ECMO provided? | Time to ECMO (hours) c | Neuroimaging at discharge | |
Control group: | |||||||||||
2 | Yes | Dopamine | Milrinone Sildenafil | CMV | 38.0 | 177 | 37 | 31.1 | Yes | 1.5 | Normal study |
4 | Yes | Dopamine | Milrinone | HFO | 37.5 | 185 | 32 | 72 | No | Bilateral cephalhematomas, thinning corpus callosum | |
5 | No | Dopamine Dobutamine | - | HFO | 38.2 | 200 | 47 | 44.9 | Yes | 24.2 | diffuse abnormality, white matter signal ↑ on T2 weighted MRI |
Low-dose IPGE1 group: | |||||||||||
3 | Yes | Dopamine Dobutamine | - | HFO | 33.6 | 131 | 46 | 10.1 | Yes | 1.5 | Normal study |
6 | No | - | Milrinone | HFO | 30.6 | 118 | 43 | 36 | Yes | Not knowna | Unknown |
High-dose IPGE1 group: | |||||||||||
1 | Yes | Dopamine Dobutamine | - | HFO | 33.5 | 142 | 45 | 39.5 | Yes | 1.2 | ↑ lactate peak suggestive of HIE |
7b | Yes | Dopamine | - | CMV | 33.7 | 121 | 63 | 34 | Yes | 4 | Grade II IVH and posterior fossa hemorrhage |
CMV, conventional mechanical ventilation; HFO, high frequency oscillator.; HIE, hypoxic ischemic encephalopathy; IVH, intraventricular hemorrhage; MRI, magnetic resonance imaging; ↑, increased.
aInfant received ECMO at another institution, time of ECMO not known.
bInfant received low-dose IPGE1 for first 24 hours though randomized to high-dose IPGE1; thereafter switched to low-dose IPGE1.
cTime from stop of study aerosol to initiation of ECMO (hours).