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. 2015 Apr 23;16:25. doi: 10.1186/s12868-015-0158-2

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© Del Rosario et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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A DsRed::LGG-1 reporter of autophagy does not provide convincing evidence for triggering of autophagy in at-risk neurons exposed to the excitotoxic insult. A) Representative images showing at-risk neurons in green (expressing P _glr-1 ::GFP) and DsRed::LGG-1 expressing cells in red. Lateral view, anterior left, dorsal up, illustration on the left describing the results expected from a putative involvement of autophagy in excitotoxicity. Expression of green labeling in the pharynx comes from the co-injection marker for the DsRed::LGG-1 label, expressing P _myo-2 ::GFP. B) Analysis of images taken from the two groups shows a similar number of at-risk neurons (green cells) showing DsRed::LGG-1 puncta. The observed small difference is not statistically significant. (t test used here) C) The average intensity of the DsRed::LGG-1 signal in at-risk neurons (green) in very similar in the two groups.