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. 2015 Mar 26;6(1):49. doi: 10.1186/s13287-015-0038-9

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© Zhang et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Characterization of human primary fetal liver cell- and human hepatic stem cell-derived human hepatocytes in Alb-TRECK/SCID mice. (A) Immunohistochemistry to distinguish between human hepatocytes stained with anti-human CK8/18 (green) antigen and anti-human nuclear antigen (aqua blue) in human primary fetal liver cell- (FLC; upper panels) and human hepatic stem cell- (HpSC; lower panels) derived humanized livers at 6 weeks after transplantation. (B) Immunohistochemistry analyses for human albumin, human CK19, and human CK8/18 expression in human primary FLC- (upper panels) and HpSC- (lower panels) derived livers at 6 weeks after transplantation. White dashed line: mouse liver region distinguished from human liver region. Nuclei were counterstained with 4′,6-diamidino-2-phenylindole (DAPI, blue). Scale bars = 100 μm. m, mouse liver region; h, human donor cell-derived human region.