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. 2015 Mar 26;6(1):49. doi: 10.1186/s13287-015-0038-9

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© Zhang et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Expressions of human hepatocyte-related genes in human primary fetal liver cell- and human hepatic stem cell-derived humanized livers. (A) Results of quantitative PCR for the expression of functional hepatocyte markers, including hALB, hAFP, hCYP3A4, hCYP2C9, and hCYP2C19, in samples taken before and about 8 weeks after human primary fetal liver cell (FLC) and human hepatic stem cell (HpSC) transplantation. Results are mean ± standard error of the mean (n ≥ 4 mice/group). (B) Heat maps for 83 human-specific drug metabolism genes and transcription factors, shown separately for independent experiments to analyze human primary FLCs and HpSCs before and at 8 weeks after cell transplantation. Human adult hepatocytes were used as a positive control. AH, adult hepatocyte; ND, not detectable; Sham, mice transplanted with saline.