Table 2. Echocardiographic parameters of the wild-type and AS160Thr649Ala knockin hearts.
| Echo parameters | Genotype | Young male | Old male | Female | |||
|---|---|---|---|---|---|---|---|
| WT (n = 14) | AS160Thr649Ala (n = 9) | WT (n = 13) | AS160Thr649Ala (n = 6) | WT (n = 9) | AS160Thr649Ala (n = 11) | ||
| %EF | 53.78 ± 1.19 | 58.13 ± 2.97 | 45.24 ± 1.02 | 45.22 ± 2.46 | 53.52 ± 1.75 | 52.65 ± 1.75 | |
| %FS | 27.37 ± 0.74 | 30.36 ± 1.93 | 22.26 ± 0.59 | 22.27 ± 1.38 | 26.16 ± 1.23 | 26.47 ± 1.07 | |
| LV Vol; d | 65.14 ± 2.40 | 58.33 ± 1.81* | 75.85 ± 1.52 | 75.82 ± 6.65 | 49.84 ± 1.74 | 51.36 ± 2.59 | |
| LV Vol; s | 30.38 ± 1.74 | 24.58 ± 2.07* | 41.05 ± 1.31 | 42.34 ± 5.34 | 22.49 ± 1.72 | 26.04 ± 2.12 | |
| LVID; d | 3.85 ± 0.06 | 3.70 ± 0.05 | 4.16 ± 0.04 | 4.12 ± 0.16 | 3.47 ± 0.05 | 3.51 ± 0.07 | |
| LVID; s | 2.81 ± 0.07 | 2.58 ± 0.09 | 3.20 ± 0.04 | 3.21 ± 0.18 | 2.50 ± 0.08 | 2.69 ± 0.08 | |
| LVAW; d | 0.73 ± 0.01 | 0.74 ± 0.01 | 0.64 ± 0.00 | 0.64 ± 0.00 | 0.69 ± 0.01 | 0.74 ± 0.01* | |
| LVAW; s | 1.00 ± 0.01 | 1.01 ± 0.03 | 0.85 ± 0.00 | 0.86 ± 0.00* | 0.90 ± 0.02 | 0.91 ± 0.02 | |
| LVPW; d | 0.72 ± 0.02 | 0.72 ± 0.03 | 0.75 ± 0.02 | 0.74 ± 0.03 | 0.66 ± 0.01 | 0.72 ± 0.02 | |
| LVPW; s | 1.01 ± 0.02 | 1.01 ± 0.03 | 0.95 ± 0.02 | 0.96 ± 0.04 | 0.93 ± 0.02 | 0.93 ± 0.03 | |
| LV Mass (AW) | 97.79 ± 2.71 | 91.89 ± 2.80 | 103.15 ± 1.96 | 102.02 ± 7.48 | 78.34 ± 2.08 | 84.07 ± 2.99 | |
| LV Mass (AW) Corrected | 78.23 ± 2.17 | 73.51 ± 2.24 | 82.52 ± 1.56 | 81.62 ± 5.99 | 62.67 ± 1.67 | 67.26 ± 2.39 | |
Echocardiography was performed on the anaesthetized AS160Thr649Ala knockin mice and wild-type littermate controls. The male mice were at age of 2 months (young male) and 8 months (old male), respectively, while the female mice were at age of 2.5 months. Student’s t-test was performed and asterisk indicates p < 0.05.