Appendix Table 5.
Predicted and Observed Events for Each Risk Score Using the RRS Definition of Premature Parental History of CHD*
| Risk Score | Predicted Events, n (%) | Observed Events, n (%) | Signed Absolute Difference | Discordance, %† | c-Statistic | Discrimination Slope |
|---|---|---|---|---|---|---|
| Total (n = 3869) | ||||||
| FRS-CHD | 367.8 (9.51) | 234 (6.05) | 3.46 | 57 | 0.68 | 0.05 |
| FRS-CVD | 516.9 (13.4) | 402 (10.39) | 2.97 | 29 | 0.71 | 0.08 |
| ATPIII-FRS-CHD | 261.8 (6.77) | 112 (2.89) | 3.87 | 134 | 0.71 | 0.05 |
| RRS | 248.9 (6.43) | 286 (7.39) | −0.96 | −13 | 0.72 | 0.05 |
| AHA-ACC-ASCVD | 356.3 (9.21) | 188 (4.86) | 4.35 | 90 | 0.70 | 0.05 |
| Men (n = 1803) | ||||||
| FRS-CHD | 233.3 (12.94) | 150 (8.32) | 4.62 | 56 | 0.69 | 0.05 |
| FRS-CVD | 332.9 (18.46) | 238 (13.20) | 5.26 | 40 | 0.71 | 0.09 |
| ATPIII-FRS-CHD | 199.0 (11.04) | 74 (4.10) | 6.93 | 169 | 0.72 | 0.05 |
| RRS | 170.4 (9.45) | 179 (9.93) | −0.48 | −5 | 0.70 | 0.05 |
| AHA-ACC-ASCVD | 216.1 (11.98) | 110 (6.10) | 5.88 | 96 | 0.71 | 0.06 |
| Women (n = 2066) | ||||||
| FRS-CHD | 134.6 (6.51) | 84 (4.07) | 2.45 | 60 | 0.58 | 0.01 |
| FRS-CVD | 183.9 (8.90) | 164 (7.94) | 0.97 | 12 | 0.69 | 0.04 |
| ATPIII-FRS-CHD | 62.8 (3.04) | 38 (1.84) | 1.20 | 65 | 0.64 | 0.01 |
| RRS | 78.5 (3.80) | 107 (5.18) | −1.38 | −27 | 0.70 | 0.03 |
| AHA-ACC-ASCVD | 140.2 (6.79) | 78 (3.78) | 3.01 | 80 | 0.67 | 0.03 |
ACC = American College of Cardiology; AHA = American Heart Association; ASCVD = atherosclerotic cardiovascular disease; ATPIII = Adult Treatment Panel III; CHD = coronary heart disease; CVD = cardiovascular disease; FRS = Framingham risk score; RRS = Reynolds Risk Score.
*
Either parent having a myocardial infarction at age <60 y.
†
Percentage discordance calculation: ([{expected percentage − observed percentage}/observed percentage] × 100).