Appendix Table 1.

Intended Age Group, Predicted Outcome, and Variables Included Among Risk Scores Being Evaluated

Risk Score	Reference	Target Age Group, y	Target Cardiovascular Events	Variables
FRS-CHD	4	30–74	Angina, MI, death from CHD, and coronary insufficiency	Age, total cholesterol level, HDL cholesterol level, BP, diabetes status, smoking status, and sex
FRS-CVD	11	30–74	Angina, MI, death from CHD, stroke, TIA, peripheral vascular disease, and heart failure	Age, total cholesterol level, HDL cholesterol level, BP, diabetes status, smoking status, sex, and antihypertensive medication use
ATPIII-FRS-CHD	5	>20	MI and death from CHD	Age, total cholesterol level, HDL cholesterol level, BP, smoking status, sex, and antihypertensive medication use
RRS	12, 22	Women: 45–80 Men: 50–80	MI, death from CHD, stroke, and coronary revascularization	Age, total cholesterol level, HDL cholesterol level, BP, diabetes status, smoking status, sex, hs-CRP level, family history, and HbA1c level*
AHA-ACC-ASCVD	13	40–79	MI, death from CHD, and stroke	Age, total cholesterol level, HDL cholesterol level, BP, diabetes status, smoking status, sex, white or African American ethnicity, and antihypertensive medication use

ACC = American College of Cardiology; AHA = American Heart Association; ASCVD = atherosclerotic cardiovascular disease; ATPIII = Adult Treatment Panel III; BP = blood pressure; CHD = coronary heart disease; CVD = cardiovascular disease; FRS = Framingham risk score; HbA_1c = hemoglobin A_1c; HDL = high-density lipoprotein; hs-CRP = high-sensitivity C-reactive protein; MI = myocardial infarction; RRS = Reynolds Risk Score; TIA = transient ischemic attack.

^*Female participants with diabetes only.