Appendix Table 4.

Predicted and Observed Events Using the AHA-ACC-ASCVD Risk Score Among MESA Participants, With Censoring at Cholesterol-Lowering Medication Use or Revascularization^*

Variable	Predicted Events, n (%)	Observed Events, n (%)	Signed Absolute Difference	Discordance, %†	c-Statistic	Discrimination Slope
Total (n = 3248)	224.2 (6.90)	99 (3.05)	3.85	126	0.76	0.08
Men (n = 1513)	136.8 (9.04)	57 (3.77)	5.27	140	0.75	0.08
Women (n = 1735)	87.4 (5.04)	42 (2.42)	2.61	108	0.74	0.08

ACC = American College of Cardiology; AHA = American Heart Association; ASCVD = atherosclerotic cardiovascular disease; MESA = Multi-Ethnic Study of Atherosclerosis.

^*Because the exact day of cholesterol-lowering medication use was not known, participants were censored at the last time observed not to be receiving this medication. Participants who reported cholesterol medication use at examination 1 or 2 were therefore excluded from the analysis.

^†Percentage discordance calculation: ([{expected percentage − observed percentage}/observed percentage] × 100).