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. 2015 Apr 29;10(4):e0124924. doi: 10.1371/journal.pone.0124924

Fig 4. SLN-STAT3 decoy ODN complexes induce apoptosis of ovarian cancer cells.

Fig 4

(A) SLN-decoy ODN induced a significant increase in apoptosis in SKOV3 and A2780 cells. After 48 hours of transfection, cell apoptosis was detected by annexin V-FITC/PI double-staining assay with flow cytometry. (B) Western blot assays showed that SLN-decoy ODN led to distinct up-regulation of Bax and cleaved caspase 3 and down-regulation of Bcl-2, pro-caspase 3 and Survivin. The data are expressed as the means ± SD of three independent experiments, ** P < 0.01 compared with NC.