Table 3. Changes of body and organ weights after hUCB-MSCs injection in PAH rats.
Week | Group | Body Wt (g) | RV/Body Wt | LV/Body Wt | Lung/Body Wt | Kidney/Body Wt | Liver/Body Wt |
---|---|---|---|---|---|---|---|
2 | C | 338.63 ± 13.88 | 0.62 ± 0.02 | 2.20 ± 0.05 | 4.18 ± 0.34 | 4.35 ± 0.16 | 4.21 ± 0.18 |
M | 278.50 ± 27.69 | 1.01 ± 0.10* | 2.34 ± 0.11 | 7.10 ± 1.15* | 4.33 ± 0.50 | 4.77 ± 0.29* | |
U | 308.56 ± 25.85 | 1.14 ± 0.21 | 2.43 ± 0.17 | 8.50 ± 1.37 | 4.52 ± 0.36 | 4.31 ± 0.41 | |
3 | C | 293.75 ± 19.45 | 0.40 ± 0.18 | 1.99 ± 0.00 | 3.24 ± 0.14 | 4.01 ± 0.14 | 4.14 ± 0.31 |
M | 266.67 ± 54.35* | 1.62 ± .0.24* | 2.16 ± 0.08 | 10.05 ± 3.67* | 4.15 ± 0.32 | 4.07 ± 0.31 | |
U | 251.00 ± 37.94 | 1.72 ± 0.33 | 2.32 ± 0.23 | 10.93 ± 2.10 | 4.37 ± 0.40 | 4.22 ± 0.40 | |
4 | C | 404.00 ± 36.77 | 0.61 ± 0.04 | 0.61 ± 0.04 | 3.68 ± 0.05 | 4.26 ± 0.30 | 3.77 ± 0.30 |
M | 248.89 ± 40.96* | 2.67 ± 0.04* | 2.67 ± 0.04 | 9.28 ± 3.29* | 4.38 ± 0.38 | 3.90 ± 0.49 | |
U | 279.29 ± 26.58 | 1.81 ± 0.15† | 1.81 ± 0.15 | 8.92 ± 1.67 | 4.02 ± 0.21 | 3.69 ± 0.39 |
*P<0.05 compared with the C group; †P<0.05 compared with the M group. C, control; M, monocrotaline; U, hUCB-MSCs; Wt, weight; RV, right ventricle; LV, left ventricle. Values are means±SD.