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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Contrast Media Mol Imaging. 2014 Oct 29;10(4):245–265. doi: 10.1002/cmmi.1629

Figure 12.

Figure 12

Responsive MRI contrast agents that detect zinc. a) The ligand of a Gd(III) chelate changes conformation when the ligand binds to Zn2+, which improves water access to Gd(III) and decreases T1 relaxation time constant (142). b) Two ligands of a Eu(III) chelate change conformation when the ligands bind to Zn2+, which accelerates the chemical exchange of water coordinated to the Eu(III) and improves CEST (150).