Figure 2.
Structure of human ALDH1A1 (N121S) apo-enzyme. (A) Ribbon representation of the structure of the homotetrameric ALDH1A1 with each monomer colored separately. (B) Ribbon representation of an ALDH1A1 monomer showing the location of cysteine 303 in the active site plus the location of ALDH1A1 N121S used for the HTS (PDB Code 4WJ9).