Table 2.

IC50 values with ALDH1A1 for compounds that inhibit dehydrogenase activity.

Compound IC50 [μM]	Structure
CM001 1.1 ± 0.1 *
CM009 5.3 ± 0.3 *
CM010 1.3 ± 0.1 *
CM020 0.45 ± 0.10
CM025 2.1 ± 0.7
CM026 0.80 ± 0.06
CM028 2.0 ± 0.1
CM037 4.6 ± 0.8
CM038 0.26 ± 0.01
CM039 0.41 ± 0.01
CM045 2.5 ± 0.5 *
CM047 0.31 ± 0.03 *
CM053 0.21 ± 0.04
CM055 0.24 ± 0.04
CM056 5.4 ± 0.8
CM057 0.92 ± 0.2
CM302 1.1 ± 0.1
CM306 3.5 ± 0.6
CM307 0.57 ± 0.09

Each value represents mean/SEM for three independent assays, each n = 3. Values calculated using 100 μM Propionaldehyde and 200 μM NAD⁺.

^*Maximum inhibition < 70%.