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Structural classes of hit compounds
| Structure | HTS Hits | Dehydrogenase Activity | |
|---|---|---|---|
| Tested | Results | ||
|
78 | 17 | 16 Inhibitors |
|
20 | 3 | CM001 |
|
10 | 1 | No effect |
|
9 | 0 | |
|
13 | 1 | No effect |
|
11 | 4 | 3 Inhibitors |
|
8 | 3 | CM047 |
|
7 | 4 | CM010 |
|
7 | 0 | |
Results of nine structural classes of esterase modulators representing 65% of the compounds identified from the esterase HTS.
