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Doxorubicinol formation in Gclm −/− and Gclm +/+ hepatocytes. (A) Representative HPLC chromatograms of doxorubicinol formation in Gclm −/− (top panel) and Gclm +/+ (bottom panel) hepatocytes. (B) Quantification by HPLC of doxorubicinol formation (area units, AU) in hepatocytes and (C) media taken from doxorubicin treatments; n=12 for each treatment. *** indicates p < 0.001 for Student’s t-test relative to wild-type for each dose.
