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. Author manuscript; available in PMC: 2015 Apr 30.
Published in final edited form as: Ren Fail. 2015 Jan 12;37(3):469–475. doi: 10.3109/0886022X.2014.996842

Figure 4.

Figure 4

Loss of MMP-8 is associated with persistent structural AKI and worsened overall health. (A) MMP-8 null mice demonstrate persistent tubular dilation, cast formation and peritubular necrosis (arrows) versus sham operated controls (lower right versus upper right). The wild-type mice after AKI recover to a similar extent as sham operated animals. (B) Independent review of representative cross-sections from kidneys shows that mice lacking MMP-8 had worsened histopathologic injury after 7 days (though similar after 24 h). (C) Mice lacking MMP-8 suffered persistent weight loss (and failure to regain weight) versus wild-types (values shown are absolute difference in percentage weight difference from baseline with sham controls). n = 6–8 per cohort, *p = 0.01 for 4(B) and *p = 0.04 for 4(C).