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. Author manuscript; available in PMC: 2016 Feb 13.
Published in final edited form as: Wound Repair Regen. 2015 Feb 13;23(1):1–13. doi: 10.1111/wrr.12245

Figure 1.

Figure 1

Burn wound repair is delayed in aged mice. A. Wound area was evaluated 0, 3, 7, 14 and 21 days following burn injury in 2 month old (young) vs 2 year old C57BL/6J mice. B. Bone marrow-derived angiogenic cells were identified by FACS as CXCR4+/Sca-1+. C. HIF1 concentrations in response to burn injury are reduced in aged mice, compared with younger ones. D. Bone marrow-derived angiogenic cells transferred from young male mice show impaired homing in older recipient mice, compared with younger ones. Donor cells were identified using the Sry gene as a marker. N, normal; B, burned.

Adapted from: Zhang X et al. Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds. J Mol Med. 2011;89(10):985-95.