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. Author manuscript; available in PMC: 2016 Jun 5.
Published in final edited form as: Chem Biol Interact. 2014 Dec 31;234:339–348. doi: 10.1016/j.cbi.2014.12.015

Figure 1.

Figure 1

Androgen metabolism in human prostate depicting the roles of AKR1C1, AKR1C2, and AKR1C3. AKR1C1: 20α-hydroxysteroid dehydrogenase; AKR1C2: type 3 3α-hydroxysteroid dehydrogenase; AKR1C3: type 5 17β-hydroxysteroid dehydrogenase; CYP 17A1: cytochrome P450 17α-hydroxylase/17,20 lyase; DHEA: dehydroepiandrosterone; HSD3B1: type 1 3β-hydroxysteroid dehydrogenase; SRD5A: 5α-reductase. Enzymes are identified by gene names.