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. Author manuscript; available in PMC: 2016 Jun 5.
Published in final edited form as: Chem Biol Interact. 2014 Dec 12;234:18–28. doi: 10.1016/j.cbi.2014.12.008

Table 2.

Effect of DEAB on ALDH isoenzymes.

Substrate IC50 (μM) mean/SEM Comments
ALDH1A1 Yes 0.057 ±0.005 Competitive tight inhibition Ki = 10 ± 3 nM
ALDH1A2 No     1.2 ± 0.1 Covalent inhibitorapparent bimolecular rate 2900 ± 160 M−1 s−1
ALDH1A3 Yes (slow)     3.0 ± 0.3
ALDH1B1 Yes (slow)     1.2 ± 0.1
ALDH1L1 No NI*
ALDH2 No   0.16 ± 0.03 Covalent inhibitor apparent bimolecular rate 86,000 ± 4200 M−1 s−1
ALDH3A1 Yes NA# Km = 5.6 μM
ALDH4A1 No NI*
ALDH5A1 Yes (slow)      13 ± 0.5
*

NI denotes no detectable inhibition.

#

NA denotes not applicable as an inhibitor.