Table 2.
Substrate | IC50 (μM) mean/SEM | Comments | |
---|---|---|---|
ALDH1A1 | Yes | 0.057 ±0.005 | Competitive tight inhibition Ki = 10 ± 3 nM |
ALDH1A2 | No | 1.2 ± 0.1 | Covalent inhibitorapparent bimolecular rate 2900 ± 160 M−1 s−1 |
ALDH1A3 | Yes (slow) | 3.0 ± 0.3 | |
ALDH1B1 | Yes (slow) | 1.2 ± 0.1 | |
ALDH1L1 | No | NI* | |
ALDH2 | No | 0.16 ± 0.03 | Covalent inhibitor apparent bimolecular rate 86,000 ± 4200 M−1 s−1 |
ALDH3A1 | Yes | NA# | Km = 5.6 μM |
ALDH4A1 | No | NI* | |
ALDH5A1 | Yes (slow) | 13 ± 0.5 |
NI denotes no detectable inhibition.
NA denotes not applicable as an inhibitor.