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. 2015 Jan 29;6(2-3):67–86. doi: 10.1007/s12672-014-0215-9

Fig. 1.

Fig. 1

Effect of AR allele strength on ETV1-induced PIN. a C57BL/6 mice carrying a “humanized” AR gene with a short (hAR 12Q) or long (hAR 48Q) polyglutamine tract were crossed with ETV1-transgenic FVB mice (ETV1 Tg) to generate hAR;ETV1 Tg mice. Experimental mice were castrated or left intact at 12 weeks, aged to 24 weeks and compared to intact hAR controls. hAR;ETV1 Tg mice were then backcrossed to FVB and crossed with Pten +/− mice to generate hAR;ETV1 Tg ;Pten +/− experimental mice with short (12Q), median (21Q) or long (48Q) Q-tracts. Experimental hAR;ETV1 Tg ;Pten +/− mice were castrated or left intact at 12 weeks, aged to an average of 43 weeks and compared to hAR;Pten +/− controls. b Representative H&E stained prostates from hAR;ETV1 Tg mice. Normal tissue (DLP), hyperplasia (DLP), and mPIN (VP) are shown. Images are ×10 with ×40 insets. c The proportion of mice with hyperplasia and mPIN in AP, DLP, and VP among hAR 12Q ;ETV1 Tg and hAR 48Q ;ETV1 Tg mice. Analysis was of 5-8 lobes per group