Fig. 9.

ETV1 effects in mouse DLP parallel those in ETS⁺ and aggressive human PCa. a A set of androgen-induced genes is significantly repressed in hAR;ETV1 ^Tg prostates and in Pten ^+/− tumors. Relative expression across groups is represented in the heatmap. b Genes downregulated in hAR ^21Q ;ETV1 ^Tg ;Pten ^+/− tumor tissue were uploaded to Oncomine and queried against “Oncomine gene expression signatures.” Significant enrichment of genes downregulated in human PCa metastases and advanced Gleason grade PCa was observed, and select concepts are shown in the molecular concept map. Node size is proportional to the number of genes shared with the primary concept. OR ≥ 4.0, p ≤ 10⁻⁶. c The heatmap shows the relative expression pattern of genes that are significantly downregulated in ETS⁺ vs. non-ETS localized tumors from the Taylor Prostate data set as well as in hAR;ETV1 ^Tg mouse prostates or DLP tumors. d The heatmap shows relative expression of genes that are significantly overexpressed in ETV1⁺ vs. non-ETS localized tumors from the Grasso Prostate data set as well as in hAR;ETV1 ^Tg mouse prostates or DLP tumors