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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: J Autoimmun. 2015 Feb 26;59:38–42. doi: 10.1016/j.jaut.2015.02.001

Figure 2. IL-2 modifies the ability of APC to support Th17 differentiation.

Figure 2

Naïve NOD CD4+ T cells were cultured under Th17 conditions with syngeneic T cell-depleted APC that were cultured for 18h with media (unstim), CpG, or CpG+ IL-2. Left panel, Representative flow cytometry data showing frequency of IL-17-producing cells in Th17 differentiation cultures. Right panel, summary data showing frequency of IL-17-producing T cells in Th17 differentiation cultures. Data are normalized to frequency of Th17 cells in cultures with unstim APC (n=3). *p=0.0034, one-way ANOVA, Tukey’s multiple comparison test. ns=not significant.