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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Brain Behav Immun. 2015 Feb 18;46:212–220. doi: 10.1016/j.bbi.2015.01.016

Fig. 1.

Fig. 1

Imipramine treatment reversed RSD-induced social avoidance 24 days after stress cessation. (A) Experimental schematic. (B) Social withdrawal was exacerbated when an aggressor was introduced in the social target trial (Trial 2) in RSD mice treated with vehicle, with a decreased time spent in the interaction zone and this was reversed with imipramine i.p. treatment (20 mg/kg). (C) RSD mice treated with vehicle spent more time in the corners during the social target trial (Trial 2). Bars represent the mean ± SEM. Means with asterisk (*) are significantly different from each other (p < 0.05). Trial 1: time without intruder; Trial 2 = time with intruder.