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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Brain Behav Immun. 2015 Feb 18;46:212–220. doi: 10.1016/j.bbi.2015.01.016

Fig. 3.

Fig. 3

Imipramine diluted in the animal's drinking water reversed RSD-induced social avoidance behavior 24 days after stress cessation. Social Avoidance test was repeated, but this time imipramine was given orally in the animal's drinking water (15 mg/kg). (A) Experimental schematic is shown. (B) Time spent in the interaction zone was significantly decreased in RSD mice treated with vehicle, when an aggressor was introduced in the social target trial (Trial 2), and was reversed with Imipramine treatment. (C) No differences were detected in the time spent in the corners between the groups. Bars represent the mean ± SEM. Means with asterisk (*) are significantly different from each other (p < 0.05). Trial 1: time without intruder; Trial 2 = time with intruder.