. Author manuscript; available in PMC: 2016 May 1.

Published in final edited form as: Brain Behav Immun. 2015 Feb 18;46:212–220. doi: 10.1016/j.bbi.2015.01.016

Table 1.

Total splenocytes of RSD animals treated with vehicle had increased mRNA expression of TNF-α at 24 days after cessation of stress, and this was attenuated with imipramine i.p. treatment (20 mg/kg). Enhanced levels of IL-6 and IL-1β mRNA were detected in both stressed groups at this time point. Imipramine did not fully block the expression of either IL-6 or IL1-β.

Gene	Total splenocytes mean relative gene expression (24 days after RSD)

	Vehicle		Imipramine

	VCON	VRSD	ICON	IRSD
TNF-α	1.01 ± 0.15^a,c	1.91 ± 0.38^b	0.58 ± 0.18^a	1.11 ± 0.06^c
IL-6	1.11 ± 0.08^a	2.92 ± 0.79^b	0.67 ± 0.20^a	1.72 ± 0.23^c
IL-1β	1.10 ± 0.23^a	2.43 ± 0.58^b	0.39 ± 0.19^a	1.76 ± 0.32^b

Means with different letters (a,b,c) are significantly different from each other (p < 0.05). CON = home caged controls; RSD = repeated social defeat; VCON = vehicle controls; ICON = imipramine controls; VRSD = vehicle repeated social defeat; IRSD = imipramine repeated social defeat.