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WISP-1 activates the β-catenin signalling pathway in fibroblasts. NRK-49F fibroblasts stably transfected with the β-catenin responsive Super Topflash reporter construct were stimulated with Wnt3a for 6 h or full-length WISP-1 for 48 h (a) or truncated WISP-1 proteins for 48 h (b). Cells were then lysed and luminescence quantified. Results are expressed as the mean ± SD (n = 3)
