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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Diagn Microbiol Infect Dis. 2015 Jan 29;82(1):49–53. doi: 10.1016/j.diagmicrobio.2015.01.009

Table 1.

MIC results of RIF and INH:

Mutations GenoType MTBDRplusassay Total no. of isolates No. of isolates MIC range of INH MIC range of RIF
katG with inhA rpoB katG with inhA rpoB n=24
Ser315Thr1 C15T Ser531Leu MUT1 MUT1 MUT3 18 18 >10 >20
Ser315Thr1 T8C Ser531Leu MUT1 MUT3A MUT3 1 1 10 >20
Ser315Thr1 T8C Ser531Leu MUT1 MUT3A MUT3 1 1 >10 >20
Ser315Thr2 T8C Ser531Leu MUT2 MUT3A MUT3 1 1 10 >20
Ser315Thr1 C15T Asp516Tyr MUT1 MUT1 Absence of WT3/4 1 1 >10 4
Ser315Thr1 C15T His526Asp MUT1 MUT1 MUT2B 1 1 >10 >20
Ser315Thr1 T8C His526Asp MUT1 MUT3A MUT2B 1 1 10 >20
katG rpoB katG rpoB n=50
Ser315Thr1 His526Cys MUT1 Absence of WT7 1 1 10 2
Ser315Thr1 His526Asn MUT1 Absence of WT7 3 2 10 0.25
1 10 0.5
Ser315Thr1 Leu533Pro MUT1 Absence of WT8 4 1 10 2
2 10 4
1 >10 4
Ser315Thr1 His526Tyr MUT1 MUT2A 2 2 3.0 >20
Ser315Thr1 Asp516Val MUT1 MUT1 3 3 10 10
Ser315Thr1 Asp516Tyr MUT1 Absence of WT3,4 2 1 10 10
1 10 0.25
Ser315Thr1 Asp516Phe MUT1 Absence of WT 3/4 1 1 10 10
Ser315Thr1 Asp516Ala MUT1 Absence of WT 3+8 1 1 3.0 10
Ser315Thr1 Ser531Leu MUT1 MUT3 25 7 3.0 >20
16 10 >20
2 >10 >20
Ser315Thr2 Ser531Leu MUT2 MUT3 2 2 10 >20
Ser315Thr1 His526Asp MUT1 MUT2B 5 2 >10 >20
3 10 >20
Ser315Thr1 His526Arg MUT1 Absence of WT7 1 1 10 >20
inhA rpoB inhA rpoB n=16
C15T WT MUT1 WT 6 6 0.5 0.25
C15T Ser531Leu MUT1 MUT3 9 6 0.5 >20
3 1 >20
C15T His526Tyr MUT1 MUT2A 1 1 1 >20
WT WT 30 25 0.1 0.25
5 0.05 0.25