TABLE 1.
Effect of Cftr-null mutation and fluoride exposure on composition of lower murine incisor enamel assessed by quantitative electron microscopical X-ray analysis (mean and standard deviation, n=3)
| Wild-type (weight %) | Fluorotic wild-type (weight %) | |||||
|---|---|---|---|---|---|---|
| secretion | mid maturation | late maturation | secretion | mid maturation | late maturation | |
| CaO | 24.7±1.5 | 45.6±2.0abc | 50.5± 0.2def | 24.8± 2.1 | 35.6± 3.9a | 4O.9±3.5d |
| P2O5 | 21.1±2.2 | 37.9±3.6hi@ | 40.7±1.7jkl | 19.5± 1.1 | 28.8± 3.5@ | 32.7±2.6j |
| Ca/P(mol/mol) | 1.49±0.13 | 1.53±0.09 | 1.57±0.06 | 1.60± 0.11 | 1.57± 0.03 | 1.58±0.02 |
| MgO×10−3 | 320±190 | 120±12 | 215±40m | 243±86 | 290±190 | 426±160 |
| SO3×10−3 | 1145±150k,l | 63± 20 | 16±11 | 880±279 | 205±155 | 49±10 |
| F×10−3 | 60±34m | 82±28p | 67±13s | 136±50 | 217±81pqr | 155±98 |
| Cl ×10−3 | 181±65 | 325±62uv | 332±18wx | 148±146 | 224±40y | 258±50z |
| Cftr-null (weight %) | Fluorotic Cftr-null (weight %) | |||||
|---|---|---|---|---|---|---|
| Secretion | mid maturation | late maturation | secretion | mid maturation | late maturation | |
| CaO | 27.9±3.2 | 27.5±1.8b | 41.9±0.9eg | 25.0±3.7 | 31.6± 4.3c | 34.8± 0.9fg |
| P2O5 | 21.3± 2.9 | 21.5±2.0h | 31.9±1.2k | 21.7±3.7 | 26.2±3.0i | 28.9± 0.9l |
| Ca/P(mol/mol) | 1.58±0.05 | 1.62±0.05 | 1.67±0.02 | 1.46± 0.05 | 1.53±0.05 | 1.52±0.04 |
| MgO×10−3 | 310±30 | 370±100 | 400±10 | 465±19k | 270±40 | 560±48m |
| SO3×10−3 | 904±75l | 643±439 | 61± 5 | 647±101 | 270±250 | 198±99 |
| F×10−3 | 56±39 | 45±18q | 51±24t | 187±24m | 179±30r | 218±45st |
| Cl×10−3 | 114±13 | 134±38u | 141±1w | 117±74 | 147±24v,y | 131± 20xz |
For each stage of development (secretory stage, early maturation or late maturation) the values were compared between the four groups. Significant differences between groups are indicated by the same character or symbol (p< 0.05; Anova, one way)