Table 3.
In-hospital mortality and odds ratio (unadjusted and adjusted) for hospital mortality, relative to normothermia (37–37.4 °C), for UK patients
| Peak temp (°C) | In-hospital mortality deaths, N (%) | Unadjusted odds ratio for in-hospital mortality (95 % CI)a | Adjusted odds ratio for in-hospital mortality (95 % CI)b |
|---|---|---|---|
| TBI/stroke (n = 45,038) | |||
| <36.0 | 931/1,266 (73.5) | 7.07 (5.61, 8.91) | 4.35 (3.51, 5.40) |
| 36.0–36.4 | 1,312/2,741 (47.9) | 2.34 (1.97, 2.77) | 2.15 (1.88, 2.46) |
| 36.5–36.9 | 2,414/7,244 (33.3) | 1.27 (1.14, 1.42) | 1.45 (1.31, 1.61) |
| 37.0–37.4 | 3,244/11,497 (28.2) | 1.00 | 1.00 |
| 37.5–37.9 | 3,084/10,249 (30.1) | 1.10 (0.98, 1.22) | 0.98 (0.90, 1.07) |
| 38.0–38.4 | 2,263/6,820 (33.2) | 1.26 (1.08, 1.47) | 0.97 (0.88, 1.08) |
| 38.5–38.9 | 1,225/3,162 (38.7) | 1.61 (1.33, 1.95) | 1.11 (0.95, 1.30) |
| 39.0–39.4 | 669/1,287 (52.0) | 2.75 (2.21, 3.43) | 1.59 (1.35, 1.88) |
| 39.5–39.9 | 304/474 (64.1) | 4.55 (3.34, 6.21) | 2.46 (1.90, 3.19) |
| 40.0+ | 262/298 (87.9) | 18.52 (13.35, 25.67) | 6.67 (4.74, 9.39) |
| CNS infection (n = 6,396) | |||
| <36.0 | 30/75 (40.0) | 2.79 (1.70, 4.57) | 2.81 (1.48, 5.33) |
| 36.0–36.4 | 83/321 (25.9) | 1.46 (1.08, 1.98) | 1.36 (0.94, 1.97) |
| 36.5–36.9 | 189/871 (21.7) | 1.16 (0.95, 1.42) | 1.22 (0.94, 1.58) |
| 37.0–37.4 | 246/1,277 (19.3) | 1.00 | 1.00 |
| 37.5–37.9 | 202/1,223 (16.5) | 0.83 (0.68, 1.02) | 0.74 (0.59, 0.94) |
| 38.0–38.4 | 148/1,016 (14.6) | 0.71 (0.57, 0.89) | 0.62 (0.48, 0.81) |
| 38.5–38.9 | 116/735 (15.8) | 0.79 (0.61, 1.01) | 0.63 (0.46, 0.87) |
| 39.0–39.4 | 88/501 (17.6) | 0.89 (0.69, 1.16) | 0.71 (0.52, 0.97) |
| 39.5–39.9 | 49/225 (21.8) | 1.17 (0.84, 1.62) | 0.95 (0.64, 1.39) |
| 40.0+ | 43/152 (28.3) | 1.65 (1.12, 2.45) | 1.00 (0.65, 1.56) |
Tests for interaction between TBI/stroke and CNS infection:
a P < 0.0001
b P < 0.0001