Figure 7.
Genes displaying altered histone marks due to the combined loss of EZH1 and EZH2 are highly susceptible to epigenetic dysregulation. A) Heatmap shows changes in H3K4me3, H3K27me3, and gene expression levels in tissues with different genotypes (3-mo-old mice). Genes showing a 2-fold change of H3K4me3 or 1.5-fold change of H3K27me3 are shown (n = 124). B) Enrichment of H3K27me3 and H3K4me3 on 5 loci is shown through the UCSC Genome Browser. The light-blue-shaded boxes represent the promoter of genes. C) Expression levels of deregulated histone and nonaltered gene sets in the context of aging (3- and 8-mo-old mice) and toxic (CCl4) administration were determined by RNA-seq. no sig. change, no significant change. *P < 0.01, Mann-Whitney U test.